The Renaissance began in Italy and spread to the rest of Europe, bringing a renewed interest in humanism, science, exploration and art. Italian culture flourished at this time, producing famous scholars, artists and polymaths such as Leonardo da Vinci, Galileo, Michelangelo and Machiavelli. Italian explorers such as Marco Polo, Christopher Columbus, Amerigo Vespucci and Giovanni da Verrazzano discovered new routes to the Far East and the New World, helping to usher in the European Age of Discovery. Nevertheless, Italy's commercial and political power significantly waned with the opening of the Atlantic trade route and the route to the Indian Ocean via the Cape of Good Hope, both of which bypassed the Mediterranean. Furthermore, the Italian city-states constantly engaged one another in bloody warfare, culminating in the Italian Wars of the 15th and 16th centuries that left them exhausted, with no one emerging as a dominant power. The weakened Italian sovereigns soon fell victim to conquest by European powers such as France, Spain and Austria.