Originally intending to have Wentz sit and learn for the 2016 season, those plans changed when on September 3, 2016, the Eagles traded quarterback Sam Bradford to the Minnesota Vikings. The same day, it was also reported that the team planned to start Wentz for the 2016 season when he became healthy. On September 5, Wentz was officially named the starter for the Eagles' 2016 season opener against the Cleveland Browns. He made his first regular season start on September 11 against the Cleveland Browns, throwing for 278 passing yards and 2 touchdowns in the 29–10 victory. He was named the Pepsi NFL Rookie of the Week for Week 1. Wentz threw for 190 yards and a touchdown in a 29–14 win over the Chicago Bears in Week 2. He became the first rookie quarterback since 1970 to win his first two games of the season and not throw an interception. During Week 3 against the Pittsburgh Steelers, Wentz finished with 301 passing yards and 2 touchdowns as the Eagles won 34-3. He was named the NFC Offensive Player of the Week for his performance against the Steelers. In his rookie season, Wentz started all 16 games for the Eagles as they finished the season with a 7–9 record. Wentz threw for a league record 379 completions by a rookie, breaking the record of 354 held by former teammate Sam Bradford, who was with the St. Louis Rams at the time. The 379 completions also set a single season franchise record, breaking the record of 346 also held by Bradford from the previous season. Wentz also set a single season franchise record with 607 pass attempts, the second highest attempts by a rookie in league history (Andrew Luck had 627 in the 2012 season).